What to expect: The hotel's fifteen conference rooms and wireless Internet access attract business travelers, while leisure visitors appreciate proximity to historic downtown Portsmouth, with its fine restaurants, shops, and historic sites. On site, the second story Riverwatch Lounge offers sweeping harbor and coastal views. The Harbor's Edge restaurant is one of Portsmouth's finest seafood venues.

Amenity highlights: Harbor views and proximity to historic downtown may be the biggest draw, but the restaurant, indoor pool, redwood sauna, and expansive meeting space make for fine on-site amenities. Sheraton's Sweet Sleeper beds—infant and canine models available—turn every room into a comfort zone, with complimentary wireless Internet access as well. The Bodywork Cafe is a "traveling wellness spa" available to guests in-room or in a private treatment room.

Insider tip: With Portsmouth's working harbor right outside your door, the opportunity to explore the harbor should not be missed. Try a cruise on Tug Alley Too, a former working tugboat that has been transformed into a tour boat. The 90-minute cruises take in historic forts, lighthouses, and Maine coastal villages. May through October, cruises can be booked at the Tugboat Store at 47 Bow Street in Portsmouth.